22. Reliable scale up/scale down in process development—New possibilities to close the gap between lab, pilot brewery, and industrial scale

Biering, J.1, Werner, M.1 and Pahl, R. H.1, (1)VLB Berlin, Berlin, GERMANY

Technical Session 7: In-Process QA
Wednesday, June 07, 2017
8:15–10:00 a.m.
Everglades A

Process and product development usually start on a small scale, and often the transfer to a large industrial scale can prove difficult, potentially leading to unexpected results. Large negative influences are seen at this scale due, for example, to altered surface/volume ratios or oxygen uptake. This can lead to additional undesired by-products, unstable processes and ultimately additional costs for the recipe transfer from the lab scale to the industrial scale. Starting with general strategies for reliable scale-up methods, the design of a new brewing system was established. The target was to find a solution on a nano-brewing scale (only a few liters of cast-out wort) with a reproducible production. Additionally, this system is fully automated to eliminate the influence of the operator and produce a standard and consistent wort quality. Based on this consistent wort quality the nano-brewery can be used for raw material checks, such as lauter performance at the very early stages of barley breeding. In terms of product development, this system allows for rapid determination of the impacts of different grist loads and raw material ratios, not only on a small scale, but with reliable results that are comparable to the industrial processes that will later be implemented. Furthermore, in addition to raw material analysis and recipe development, the capacity of this system for early testing of process development was also a main target of its development. After the engineering and construction phase of this equipment, the next stage was the development of the automization, before finally the process parameters were optimized for the reliable scale-up functionality of this nano-brewery system.

Jan Biering apprenticed at Kulmbacher Brauerei Germany (1995–1997); studied biotechnology/brewing science at TU Berlin (1997–2003); was plant manager at Schlossbrauerei Schwarzbach (2003–2011); and since 2012 has been a scientific assistant and consultant at VLB Berlin.

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